CD8 alpha Rat mAb

FC-1:100

Rat

Unconjugated

Unmodified

12525

Cd8a

IgG2a

Monoclonal Antibody

FC-H2

A synthesized peptide derived from mouse CD8A

Immunology

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Affinity Purified

Liquid

Liquid in 0.01M PBS, pH 7.4, 0.2%(w/v) BSA, 0.09%(w/v) NaN3

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.